Ebola vaccines at a la glance

Ebola vaccine candidates are currently being evaluated in phase I–III clinical trials conducted in Africa, the EU and the US. Although preclinical development of candidate vaccines utilise different platforms, including inactivated viral particles, DNA vaccines, recombinant viral vectors, recombinant proteins, subunit proteins and virus-like particles, the most advanced vaccine candidates are based on viral vectors […]

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Controlled Human Infection Model (CHIM) studies

In a Controlled Human Infection Model (CHIM) study, a well-characterised strain of an infectious agent is given to carefully selected adult volunteers in order to better understand human diseases, how they spread, and find new ways to prevent and treat them. These studies play a vital role in helping to develop vaccines and treatments for infectious diseases. A very […]

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Ebola outbreak in Republic Democratic of the Congo: switching from MEURI (Monitored Emergency Use of Unregistered and Investigational Interventions) to a RCT (Randomized Clinical Trial) for 4 experimental medications in the treatment of Ebola Virus Disease

An international research team has begun patient enrollment in a clinical trial testing multiple investigational Ebola therapies in the Democratic Republic of the Congo (DRC). The randomized, controlled trial is enrolling patients of any age with confirmed Ebola virus disease (EVD). The trial is conducted at a treatment unit in the city of Beni operated by ALIMA (The Alliance […]

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