EXCO2019, the first and only global expo dedicated to the players active in the field of development cooperation

R-Evolution Worldwide Community Interest Company joined in EXCO2019, the first and only global expo dedicated to the innovative solutions provided by the actors of development cooperation: national and international agencies, governments, financial institutions, civil society and in particular, the private sector.

During EXCO2019, the players active in the field and those willing to enter development cooperation, had the possibility to meet financial Institutions, Government representatives, development agencies and international organizations, in order to engage in new business relationships aimed at creating partnerships to find solutions for sustainable development.

Malaria incidence stopped to decrease and begun to increase, especially in the 10 countries with the highest burden of malaria

R-Evolution Worldwide Community Interest Company participated as observer to the 15th WHO meeting of the Malaria Policy Advisory Committee (MPAC). The meeting highlighted how in the last couple of years the malaria incidence stopped to decrease and begun to increase, especially in the 10 countries with the highest burden of malaria. According to the World malaria report 2018, indeed, there were 219 million cases of the disease in 2017, compared to 217 million the year before. Every two minutes, a child dies of malaria. In 2017, the estimated global tally of malaria deaths stood at 435.000. All the 10 countries with the highest malaria burden are in Africa: Burkina Faso, Cameroon, Democratic Republic of the Congo, Ghana, Mali, Mozambique, Niger, Nigeria, Uganda and United Republic of Tanzania.


With comments as “the project is likely to have a significant impact”, and “this project will make a substantial contribution to the expected impact”, the reviewers of the European Union agency EDCTP approved for funding another new project: “LiberHetica: increasing the ethics capacity of oversight for clinical trials in Liberia by establishing European-African collaborations that facilitates implementation of efficient processes …”. A great team lead by Liberian institutional rapresentatives made this come true, therefore I would like to thank Dr. Bolay Fotorma, Jemee Tegli, Dr. Stephen B. Kennedy, Gloria Mason, and Cecilia Morris.

The way to build bridges instead of walls is still long.

The way to build bridges instead of walls is still long, but I am happy to have got European Union funding for this project. Africlinique project aims to increase the capacity to oversight clinical trials addressing deadly diseases in Central African countries (specifically Republic of the Congo, Democratic Republic of the Congo, Cameroon and Gabon). This achievement was made possible thanks to the exciting proactiveness and invaluable collaboration of a Central African team lead by Prof. Francine Ntoumi, already coordinator of Central Africa Network on Tuberculosis, HIV/AIDS and Malaria (CANTAM).

Working on an idea for a brand new project

The ATTENTION project is aimed to improve the access to effective health services for the children in the orphanages and Interim Care Centers (ICCs) of Sierra Leone.

Indeed there is a huge lack of healthcare references for the children hosted in these facilities.

It is planned to finance this project by a call proposal to the Small Charities Challenge Fund (UKAid – DFID), by establishing an ad-hoc applying consortium.

EuropeAid, from EU – a major financial resource for overseas humanitarian projects

Directorate General Development and Cooperation – EuropeAid was formed on 1 January 2011 following the merger of the EuropeAid Cooperation Office (AIDCO) with the Directorate General for Development and Relations with African, Caribbean and Pacific – ACP – States (DEV).

EuropeAid focused on maximising the value and impact of aid funding by making sure support provided in a manner which complies with EU development objectives and the United Nations‘ Millennium Development Goals in a speedy and accountable fashion. Effective implementation and delivery of aid also helps the Commission and the EU as a whole to attain a higher profile on the world stage. The European Union is the world’s largest aid donor.

The Commission’s Directorate-General for International Cooperation and Development (DG DEVCO) is responsible for designing European international cooperation and development policy and delivering aid throughout the world. Its mission is to help reduce and ultimately eradicate poverty in developing countries through the promotion of sustainable development, democracy, peace and security.

It works on policy formulation at a global and sectoral level. The main intervention areas covered are: Trade and regional integration, Environment and the sustainable management of natural resources, Infrastructure, communications and transport, Water and energy, Rural development, Governance, democracy and human rights, Peace and security, Human development, Social cohesion and employment.

Directorate-General awards grants and contracts to implement projects or activities that relate to the European Union’s external aid programmes. To ensure that EuropeAid’s work to improve people’s lives is recognised, a set of visibility guidelines have been produced. These guidelines ensure that aid projects acknowledge the funding support they receive from Commission budgets. They also help to raise the general profile of the EU across the world.

Grants are direct financial contributions provided to organisations, or to projects carried out by them. Most of the time, the Commission attributes them through calls for proposals.

Contracts are awarded through tendering procedures to purchase services, supplies or works.

Both contracts and grants are awarded for activities contributing to specific development goals.

Development aid is financed directly by the EU budget (70%) as part of the financial instruments for external action and also by the European Development Fund (EDF).

R-Evolution Worldwide – Sierra Leone, a new local Community Based Organization

R-Evolution Worldwide – Sierra Leone is starting to operate in the Western Area Urban and Rural District of Freetown, Sierra Leone.

R-Evolution Worldwide – Sierra Leone is local community-based organization, registered to the Ministry of Social Welfare, Gender and Children’s affairs (MSWGCA), the local council and the Ministry of Health and Sanitation (MoHS).

R-Evolution Worldwide – Sierra Leone is established by a group of Sierra Leoneans who will be advocating on the following areas:
·         Early Marriage
·         Teenage Pregnancy
·         Child Labour
·         Sexual Offence
·         Child Healthcare
·         Hygiene and Sanitation
·         Food Education
·         Prevention of Youth Migration, awareness raising and information campaigns on the risk of irregular migration.

The organization is created as an independent non-profit organisation (local Community Based Organisation – CBO) with strict political and religious neutrality, with a particular respect for the principle of non-discrimination based on race, ethnic, political and religious orientation.

Ebola vaccines at a la glance

Ebola vaccine candidates are currently being evaluated in phase I–III clinical trials conducted in Africa, the EU and the US. Although preclinical development of candidate vaccines utilise different platforms, including inactivated viral particles, DNA vaccines, recombinant viral vectors, recombinant proteins, subunit proteins and virus-like particles, the most advanced vaccine candidates are based on viral vectors engineered to serve as antigen delivery platforms that encode the full length of the surface glycoprotein of the Ebola virus.

Examples of viral vectors expressing ebolavirus glycoproteins include recombinant human adenovirus (Ad26), recombinant simian adenovirus (chimpanzee Ad3), recombinant vaccinia virus (MVA) and a live vesicular stomatitis virus (rVSV) used alone or in prime-booster regimens.

The genus Ebolavirus, a member of the family of Filoviridae, is comprised of five distinct species: Bundibugyo (BDBV), Ebola virus (EBOV) (formerly designated as Zaire ebolavirus, ZEBOV), Reston (RESTV), Sudan (SUDV) and Taï Forest (TAFV). The EBOV and SUDV species are the predominant causes of most EVD outbreaks. Glycoproteins from the different filoviruses show a high degree of diversity at the nucleotide and amino acid levels (60-65% conservation), implying that vaccines for protection against different filovirus infections would have to express and induce an immune response to several glycoproteins and would optimally be multivalent encoding glycoproteins from different viral species into one vaccine regimen. Single dose or prime-boost regimens are being explored in ongoing clinical trials.

To date, at least 15 EVD vaccines are being developed (in North America, Europe, Russia and China), with four main candidates in varying advanced stages of human testing. These include the two most advanced – rVSV-ZEBOV (Merck) and ChAd3-EBO Z (GSK) – as well as a prime-boost regimen of Ad26.ZEBOV and MVA-BN-Filo developed by J&J/Bavarian Nordic, and a recombinant particle made of EBOV glycoprotein produced in an insect cell line, developed by the biotech company Novavax.

The two lead vaccine candidates started human clinical trials in September 2014 and data on their safety and immunogenicity profiles were ready by December-January, breaking all records in terms of vaccine trial Phase I timelines. WHO played a key role in this endeavor, by identifying and coordinating numerous trial sponsors to test the vaccines contemporaneously in the US, Canada, and several countries in Europe and Africa.

These two vaccines are now in Phase II/III trials in the three affected countries. The trial collaborations underway are: a ring vaccination trial of VSV-EBOV in Guinea, organized through a large international consortium including WHO, MSF, Canada, Norway and universities in the UK, Switzerland and the US; and a cluster based, non-blinded, individually randomized trial of rVSV-ZEBOV in Sierra Leone under a Sierra Leonean-US-CDC collaboration. A Phase II trial of both vaccines was carried out in Liberia under a Liberian government – US-NIH collaboration. This trial was completed at the end of April, and it is not known if trials in Liberia will continue. In the meantime, phase II trials of the GSK vaccine are slated to start in Cameroon, Ghana, Mali, Nigeria and Senegal in the second half of 2015.

Pharmaceutical companies developing the vaccines have committed to ramp up production capacity in case of proven vaccine efficacy and the need for deployment. This could be the fastest vaccine roll-out in history.

A comprehensive list of the EVD clinical trials can be found on the WHO International Clinical Trials Registry.

Controlled Human Infection Model (CHIM) studies

In a Controlled Human Infection Model (CHIM) study, a well-characterised strain of an infectious agent is given to carefully selected adult volunteers in order to better understand human diseases, how they spread, and find new ways to prevent and treat them. These studies play a vital role in helping to develop vaccines and treatments for infectious diseases.

A very important application of the se studies are the field of malaria clinical research. Indeed in the Controlled human malaria infection (CHMI) studies, healthy volunteers are infected with Plasmodium falciparum to assess the efficacy of novel malaria vaccines and drugs, becoming a vital tool to accelerate vaccine and drug development.

Ebola outbreak in Republic Democratic of the Congo: switching from MEURI (Monitored Emergency Use of Unregistered and Investigational Interventions) to a RCT (Randomized Clinical Trial) for 4 experimental medications in the treatment of Ebola Virus Disease

An international research team has begun patient enrollment in a clinical trial testing multiple investigational Ebola therapies in the Democratic Republic of the Congo (DRC). The randomized, controlled trial is enrolling patients of any age with confirmed Ebola virus disease (EVD). The trial is conducted at a treatment unit in the city of Beni operated by ALIMA (The Alliance for International Medical Action), a medical humanitarian organization, that is making the difference in a very difficoult scenario: “the situation is worrying, as we are hospitalizing a higher number of cases and the majority of these new cases are patients who were not previously registered as known contacts,” said Dr. Rouafi Oummani, ALIMA’s medical coordinator in Beni.

The trial, which will expand to additional DRC districts, is organized through an international research consortium coordinated by the World Health Organization (WHO). It is led and funded by the National Institute for Biomedical Research (INRB), part of the DRC Ministry of Health, and the National Institute of Allergy and Infectious Diseases (NIAID), part of the U.S. National Institutes of Health, and also involves several additional international partners.

“Combatting Ebola requires a comprehensive response that draws on the strengths of all areas of public health. Biomedical research can lead to critical new tools, such as potentially life-saving therapies,” said NIAID Director Anthony S. Fauci., M.D. “Through scientifically and ethically sound clinical trials, we hope to efficiently and definitively establish the safety and efficacy of these investigational Ebola treatments, offering new ways to save lives.”

After the end of the 9th EVD outbreak in RDC, on Aug. 1, 2018, the DRC Ministry of Health declared the country’s 10th outbreak of EVD. As of Nov. 25, 2018, 240 deaths out of 419 confirmed and probable cases of EVD have been reported in the northeastern provinces of North Kivu and Ituri. Under the leadership of the DRC Ministry of Health, the WHO has coordinated the outbreak response with several international partners. NIAID, along with the U.S. Centers for Disease Control and Prevention, the U.S. Agency for International Development (USAID), and other U.S. government partners, have provided guidance and support to the multi-sectoral outbreak response.

“We urgently need a safe and effective treatment for this deadly disease,” said DRC Minister of Health Oly Ilunga Kalenga, M.D., Ph.D. “As we face a 10th outbreak of Ebola, we hope this clinical trial will give us more information about how best to treat patients.”

The trial aims to compare mortality among patients who receive one of three investigational Ebola drugs with a control group of patients who receive the investigational monoclonal antibody cocktail treatment ZMapp, developed by Mapp Biopharmaceutical, Inc. The therapies being tested include: mAb114, a single monoclonal antibody developed by NIAID, with early support from the INRB; and remdesivir (also known as GS-5734), an antiviral drug developed by Gilead Sciences, Inc. The trial has been approved to begin enrolling patients in these three groups, and plans are underway to amend the trial to include REGN-EB3 (also known as REGN3470-3471-3479), a monoclonal antibody cocktail developed by Regeneron Pharmaceuticals, Inc.

The participating Ebola treatment units will continue to provide all participants with supportive care for EVD. Ebola care includes supportive oral and/or intravenous fluids, electrolyte replacement, maintaining oxygen status and blood pressure, and pain management.

The investigational treatments have varying levels of data to support their use from testing in the laboratory, animals, and humans. However, none has been approved for treating EVD. ZMapp is the only investigational treatment previously tested in a randomized, controlled efficacy trial. Results from that study, conducted in the U.S. and West Africa during the 2014 to 2016 outbreak, suggested that ZMapp appeared to be beneficial, but as the outbreak waned, the trial ultimately could not enroll enough participants to definitively establish the drug’s efficacy.

The investigational treatments also have been administered to most of the Ebola patients in the current outbreak in the DRC under an ethical framework developed by the WHO called Monitored Emergency Use of Unregistered and Investigational Interventions (MEURI). However, this emergency-use mechanism cannot yield generalizable evidence on how well the treatments work.

“A randomized, controlled clinical trial is necessary to obtain reliable data about the safety and efficacy of investigational Ebola treatments,” said H. Clifford Lane, M.D., director of NIAID’s Division of Clinical Research. “It is possible to conduct rigorous clinical research in an outbreak setting, and we anticipate this trial will provide useful data.”

Professor Jean-Jacques Muyembe-Tamfum, M.D., Ph.D. (which was part of the research team that investigated the first know outbreak of Ebola disease in 1976), director-general of the INRB, and Richard T. Davey, Jr., M.D., deputy director of NIAID’s Division of Clinical Research, are co-principal investigators for the study.

Trial participants will be randomly assigned to receive one of the investigational treatments by intravenous infusion. Site clinicians will monitor patients’ symptoms and take blood samples for laboratory tests. Patients will remain in the Ebola treatment unit until they fully recover from the disease. They will be asked to return to the clinic approximately two months after receiving treatment for a check-up and to provide additional blood samples for laboratory tests.

Plans are underway to expand the trial beyond the ALIMA site in Beni to additional Ebola treatment units operated by medical humanitarian organizations, including International Medical Corps. The trial also may be adapted to continue across more than one outbreak and in several countries. The number of participants enrolled in the trial ultimately will depend on the evolution of Ebola outbreaks. The study is designed to enroll 112 patients per arm, potentially over multiple outbreaks.

“This clinical trial marks a significant and important step forward for the DRC and our international partners,” said Dr. Muyembe. “We are eager to learn more about each of these investigational treatments as we continue to work tirelessly to identify new cases, trace contacts and control the spread of disease.”

An independent data and safety monitoring board will regularly review the study data. For more information, visit ClinicalTrials.gov and search identifier NCT03719586.

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